2006-2010
141.) Daniel E Fraiman, Bernardo Pando, Sheila Dargan, Ian Parker, and Silvina M.
Ponce Dawson. Analysis of puff dynamics in oocytes: interdependence of puff amplitude and inter-puff interval. Biophys. J. 90:3897-3907, 2006. [PDF] 44
142.) Stutzmann, G.E., Smith, I., Caccamo, A., Oddo, S., LaFerla, F.M. & Parker, I. Enhanced ryanodine receptor recruitment contributes to Ca2+ disruptions in young, adult and aged Alzheimer's didsease mice. J. Neurosci. 26:5180-5189, 2006. [PDF] 290
143.) Parker, I. Plasmalemmal Ca2+ signaling in arterial smooth muscle: It's elementary. J. Gen.Physiol. 127: 605-609. 2006 [PDF] 3
144.) Cahalan, M., Parker, I. Imaging the choreography of lymphocyte trafficking and the immune response. Curr. Op. Immunol. 18: 1-7, 2006. [PDF] 67
145.) Sanna, M.G., Wang, S-K., Gonzalez-Cabrera, P.J., Don, A.m Marsolais, D., Matheu, M.P., Wei, S.H., Parker, I., Jo, E., Cheng, W-C., Cahalan, M.D. & Rosen, H. Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo. Nature Chemical Biology. Online publication doi:10.1038/nchembio804, 2006. [PDF] 390
**Evaluated as 'Recommended' by the Faculty of 1000** [view]
146.) Rose, H.J., Dargan, S., Shuai, J. & Parker, I. 'Trigger' events precede calcium puffs in Xenopus oocytes. Biophys. J. 91:4024-4032, 2006. [PDF]. 48 **Evaluated as 'Recommended' by the Faculty of 1000** [view]
147.) Shuai, J., Rose, H.J. & Parker, I. The number and spatial distribution of IP3 receptors underlying calcium puffs in Xenopus oocytes. Biophys. J. 91:4033-4044, 2006. [PDF] .94
148.) Demuro, A. & Parker, I. Imaging single-channel calcium microdomains. Cell Calcium40:413-422, 2006. 2006. [PDF] 90
149.) Reudiger, S., Shuai, J.W., Huisinga, W., Nagaiha, Ch., Warnecke, G., Parker, I. & Falcke, M. Hybrid stochastic and deterministic simulations of calcium puffs. Biophys. J. 93:1847-1857. 2007. [PDF] 121
150.) Shuai, J.W., Pearson, J.E., Foskett, J.K., Mak, D.-O. & Parker, I. A kinetic model of single and clustered IP3 receptors in the absence of Ca2+ feedback. Biophys. J. 93:1151-1162, 2007. [PDF] 93
151). Stutzmann, G.E., Smith, I., Caccamo, A., Oddo, S., Parker, I. & LaFerla, F. Enhanced ryanodine-mediated calcium release in mutant PS1-expressing Alzheimer's mouse models. Ann. N.Y. Acad. Sci. 1097:265-277, 2007. [PDF] 114
152). Garrod, K.R., Wei, S.H., Parker, I. & Cahalan, M.D. Natural killer cells actively patrol peripheral lymph nodes forming stable conjugates to eliminate MHC-mismatched targets. Proc. Natl. Acad. Sci. USA 104:1208-12086, 2007. [PDF] 89
153). Wei, S.H., Safrina, O., Yu, Y., Garrod, K.Y., Cahalan, M.D. & Parker, I. Ca2+ signals in CD4+ T cells during early contact with antigen-bearing dendritic cells in lymph node. J. Immunol. 179:1586-1594, 2007. [PDF] 90
154). Matheu, M.P., Deane, J.A., Parker, I., Fruman, D.A. & Cahalan, M.D. Class IA phosphoinositide 3-kinase modulates basal lymphocyte motility in the lymph node. J. Immunol. 179:2261-2269, 2007. [PDF] 42 **Evaluated as 'Recommended' by the Faculty of 1000**
155) Ionescu, L., White, C., Cheung, K-H., Shuai, J., Parker, I., Pearson, J.E., Foskett, J.K., & Mak, D-O.O. Mode switching is the major mechanism of ligand regulation of InsP3 receptor calcium release channels. J. Gen. Physiol. 130:631-645, 2007. [PDF] 65
156) Demuro, A. & Parker, I. Multi-dimensional resolution of elementary Ca2+ signals by simultaneous multi-focal imaging. Cell Calcium43:367-374, 2007. [PDF] 36
157) Cahalan, M.D. & Parker, I. Choreography of cell motility and interaction dynamics imaged by two-photon microscopy in lymphoid organs. Ann. Rev. Immunol.
26:585-626, 2008
. [PDF with linked videos] [ARI website] 291
158) Green, K.N., Demuro, A., Akbari, Y., Hit, B.D., Smith, I.F., Parker, I. & LaFerla, F.M. SERCA pump activity is physiologically regulated by presenilin and regulates amyloid b production. J. Cell. Biol. 181:1107-1116, 2008. [PDF] Commentary in J.C.B. "Alzheimer's protein controls calcium's ins and outs" [PDF] Commentary on Alzforum 278
159) Smith, I.F., Wiltgen, S.M. & Parker, I. Localization of puff sites adjacent to the plasma membrane : Functional and spatial characterization of Ca2+ signaling in SH-SY5Y cells using membrane-permeant caged IP3. Cell Calcium45:65-76, 2009 [PDF].98
160) Shuai, J., Pearson, J. & Parker, I. Modeling Ca2+ feedback on a single inositol 1,4,5-trisphosphate receptor and its modulation by Ca2+ buffers. Biophysical Journal. 95:3738-3752, 2008. [PDF] 41
161) Penna, A., Demuro, A., Yeromin, A.V., Zhang, S.L., Safrina, O., Parker, I. & Cahalan, M.D. The CRAC channel consists of a tetramer formed by Stim-induced dimerization of Orai dimers. Nature Advanced online publication. 2008. DOI:10.1038/nature07338. [PDF] [supplementary info] . [Link to Nature website]. Selected as "Editor's Choice" by Science Signaling. **Evaluated as 'Must read' by the Faculty of 1000** [View] . 410
162) Matheu, M.P., Beeton, C., Garcia, A., Chi, V., Rangaraju, S., Safrina, O., Monaghan, K., Uemura, M.I., Li, D., Pal, S., de la Maza, L.M., Monuki, E., Flugel, A., Pennington, M.W., Parker, I., Chandy, K.G. & Cahalan, M.D. Imaging of effector memory T cells during a delayed-type hypersensitivity reaction and suppression by KV1.3 channel block. Immunity 29:602-614, 2008. [PDF] [News feature on UCI website] 199
163) Sen, D., Deerinck, T.J., Ellisman, M.H., Parker, I. & Cahalan, M.D. Quantum dots for tracking dendritic cells and priming an immune response in vitro and in vivo. PLoS ONE 3:e3290, 2008. [free access to article on PLoS website] 76
164) Yamasaki, M., Demuro, A. & Parker, I. cADPR modulates SERCA activity in Xenopus oocytes. Cell Calcium 45:293-299, 2009. PDF. 29
165) Smith, I.F. & Parker, I. Imaging the quantal substructure of single IP3R channel activity during Ca2+ ouffs in intact mammalian cells. Proc. Natl. Acad. Sci. USA 106:6404-6409, 2009. PDF .163
166) Zeller, s., Rudiger, S., Engel, H., Sneyd, J., Warnecke, G., Parker, I. & Falcke, M. Modeling of the modulation by buffers of Ca2+ release through clusters of IP3 receptors. Biophys. J. 97:992-1002, 2009. PDF 30
167) Smith, I.F., Wiltgen, S.W., Shuai, J & Parker, I. Ca2+ puffs originate from preestablished clusters of inositol trisphosphate receptors. Science Signaling 2: Issue 98: ra77, 2009. Abstract Free full-text access 74
168) Khoury, M.K., Parker, I. & Aswad, D.W. Acquisition of chemiluminescent signals from immunoblots with a digital single-lens reflex camera. Anal. Biochem. 397:129-131, 2010. PDF 49
169) Garrod, KR., Liu, F.C., Forrest, L.E., Parker, I., Kang, S.M. & Cahalan, M.D. NK cell patrolling and elimination of donor-derived dendritic cells favor indirect alloreactivity. J. Immunol. 184:2329-2336, 2010. PDF. 66
170) Demuro, A., Parker, I. & Stutzmann, G. Calcium signaling and amyloid toxicity in Alzheimer's disease. J. Biol. Chem.285:12463-12468, 2010. free full text access 374
171) Sen, D., Forrest, L., Kepler, T.B., Parker, I. & Cahalan, M.D. Selective and site-specific mobilization of dermal dendritic cells and Langerhans cells by Th-1 and Th-2-polarizing adjuvants. Proc. Natl. Acad. Sci. USA 107:8334-8339, 2010. PNAS website PDF 79
172) Yamasaki-Mann, M., Demuro, A. & Parker, I. Modulation of ER Ca2+ store filling by cADPR promotes IP3-evoked Ca2+ signals. J. Biol. Chem. 285:25053-61, 2010. PDF Free full text access 28
173) Reissner, K.J., Pu, L., Schaffhausen, J.H., Boyle, H.D., Smith, I.F., Parker, I. &Carew, TJ. A novel postsynaptic mechanism for heterosynaptic sharing of short-term plasticity. J. Neurosci. 30:8797-8806, 2010. PDF 10
174) Wiltgen, S.M., Smith, I.F. & Parker , I. Superresolution localization of single functional IP3R channels utilizing Ca2+ flux as a readout. Biophys. J. 99:437-446, 2010. PDF 38
175) Cardenas, C., Miller, R.A., Smith, I., Bui, T., Molgo, J., Muller, M., Vais, H., Cheung, K-H., Yang, J., Parker, I., Thompson, C.B., Birnbaum, M.J., Hallows, K.R. &Foskett, J.K. Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria. Cell 142:270-283, 2010. PDF. Cell Website. Preview by Green & Wang PDF 692
176) Parker, I. & Smith, I.F. Recording single-channel activity of inositol trisphosphate receptors with a microscope, not a patch clamp. J. Gen. Physiol. 136:119-127, 2010. PDF Perspectives overview by Sharona Gordon PDF 53
2011-2015
177) Smith, I.F., Shuai, J., & Parker, I. Active generation and propagation of Ca2+ signals within tunneling membrane nanotubes. Biophys. J. 100:pL37-39, 2011. PDF link to supplemental material. 70
178) Yamasaki-Mann, M., & Parker, I. Enhanced ER Ca2+ store filling by overexpression of SERCA2B promotes IP 3-evoked puffs. Cell Calcium 50:36-41 (2011). PDF 13
179) Demuro, A., Penna, A., Safrina, O., Yeromin, A.V., Amcheslavski, A., Cahalan, M.D. & Parker, I. Subunit stoichiometry of human Orai1 and Orai3 channels in closed and open
states. PNAS 108:17832-7, 2011. PDF Abstract 91
180) Demuro, A., Smith, M. & Parker , I. Single-channel Ca2+ imaging implicates Ab 1-42 amyloid pores in Alzheimer's disease pathology. J. Cell Biol. 195:515-524, 2011. PDF Abstract 163 JCB 'Focal Point' by Ben Short Alzforum commentaries by Bezprozvanny, Kagan
181) Thurley, K., Smith, I., Tovey, S.C., Taylor, C.W., Parker, I. & Falcke, M. Timescales of IP3-evoked Ca2+ spikes emerge from Ca2+ puffs only at the cellular level. Biophys. J. 101:2638-2644, 2011. PDF 47
182) Matheu, M.P., Cahalan, M.D. & Parker, I. Induction of an immune response for imaging antigen-peresenting cell/T cell interactions. Cold Spring Harbor Protocols 2011 pdb. prot5566. 4
183) Matheu, M.P., Cahalan, M.D. & Parker, I. General approach to adoptive transfer and cell labeling for immunoimaging.
Cold Spring Harbor Protocols 2011 pdb. prot5565.9
184) Matheu, M.P., Cahalan, M.D. & Parker, I. In vivo lymph node imaging. Cold Spring Harbor Protocols 2011 pdb. prot5568. 7
185) Matheu, M.P., Cahalan, M.D. & Parker, I. In situ lymp node imaging. Cold Spring Harbor Protocols 2011 pdb. prot5567. 5
186) Dickinson, G.D., Swaminathan, D. & Parker, I. The probability of triggering calcium puffs is linearly related to the number
of inositol trisphosphate receptors in a cluster. Biophys. J. 1021826-1836, 2012. PDF 40
187) Matheu, M.P., Su, Y., Greenberg, M.L., Blanc, C.A., Parker, I., Scott, D.W. & Cahalan, M. D.
Toll-like receptor 4-activated B cells out-compete Toll-like receptor 9-activated B cells to establish peripheral immunological tolerance. PNAS 109:E1258-1266, 2012 www.pnas.org/cgi/doi/10.1073/pnas.120515010917 
188) Ullah, G., Parker, I., Mak, D-O. & Pearson, J.E. Multi-scale data-driven modeling and observation of calcium puffs. Cell Calcium 52:152-160, 2012. PDF 38
189) Yamasaki-Mann, M., Demuro, A. & Parker, I. Cytosolic [Ca2+] regulation of IP3-evoked puffs. Biochem. J., 449:167-173, 2013. Biochem. J. website PDF 8
190) Dickinson, G.D. & Parker, I. Temperature-dependence of IP3-mediated local and global Ca2+ signals. Biophys. J. 104:386-396, 2013. BJ website PDF 8
191) Adam P. Siebert, Zhongming Ma, Jeremy D. Grevet, Angelo Demuro, Ian Parker, and J. Kevin Foskett. Structural and Functional Similarities of Calcium Homeostasis Modulator 1 (CALHM1) Ion Channel With Connexins, Pannexins and Innexins. J. Biol. Chem. doi:10.1074/jbc.M112.409789, 2013. PDF 81 
192) Demuro, A. & Parker, I. Cytotoxicity of intracellular Ab42 amyloid oligomers involves Ca2+ release from the ER by stimulated production of inositol trisphosphate. J. Neurosci. 33:3824-3833, 2013. J. Neurosci website. PDF Commentary on Alzforum. Recommended as 'new finding' by Faculty of 1000 Prime. (View) 91 
193) Matheu, M.P., Teijaro, J.R., Walsh, K.B., Greenberg, M.L., Marsolais, D., Rosen, H., Oldstone, M.B.A. & Cahalan, M.D. Three phases of CD8 T cell response in the lung following H1N1 influenza infection and sphingosine 1 phosphate agonist therapy. PLOS ONE 8(3): e58033. doi:10.1371/journal.pone.0058033, 2013. PDF PLOS ONE website 26
194) Greenberg, M.L., Yu, Y., Leverrier, S., Zhang, S.L., Parker, I. & Cahalan, M.D. Orai1 Function is Essential for T Cell Homing to Lymph Nodes. J. Immunol. doi: 10.4049/jimmunol.1202212 2013. Journal website PDF 24
195) Dickinson, G.D. & Parker, I. Factors determining the recruitment of inositol trisphosphate receptor channels during calcium puffs. Biophys. J. 105:2474-2484, 2013. PDF 20
196) Greenberg, M.L., Weinger, J.G., Matheu, M.P., Carbajal, K.S., Parker, I., Macklin, W.B., Lane, T.L. & Cahalan, M.D.Two-photon imaging of remyelination of spinal cord axons by engrafted neural precursor cells in a viral model of multiple sclerosis. PNAS 111:E2349-2355, 2014. PNAS website PDF 24
197) Smith, I.F., Swaminathan, D., Dickinson, G.D. & Parker, I. Single-molecule tracking of inositol trisphosphate receptors reveals differing motilities and distributions. Biophys. J. 107:834-845, 2014. PDF 25 
198) Wiltgen, S.M., Dickinson, G.D., Swaminathan, D. & Parker, I. Termination of calcium puffs and coupled closings of inositol trisphosphate receptor channels. Cell Calcium. 56:157-168, 2014. PDF 24
199) Ellefsen, K., Settle, B, Parker, I. & Smith, I. An algorithm for automated detection, localization and measurement of local calcium signals from camera-based imaging. Cell Calcium.56:147-156, 2014. PDF 46
200) Sanderson, M.J., Smith, I., Parker, I. & Bootman, M.D. Fluorescence Microscopy. Cold Spring Harbor Protoc. doi: 10.1101/pdb.top071795, 2014. PDF 125
201) Matheu, M.P., Cahalan, M.D. & Parker, I. Intravital Imaging of the Immune System. In: Advances in Intravital Microscopy, Ed. Weingert, R. Springer. 2014 PDF
202) Ruckl, M., Parker, I., Marchant, J., Nagaiah., C., Johenning, F.W. & Rudiger, S. Modulation of elementary calcium release modulates a transition from puffs to waves in an IP3R cluster model. PLOS Computational Biol. DOI: 10.1371/journal.pcbi.1003965. 2015. Open access PLOS website PDF 30

203) Amcheslavsky, A., Wood, M.L., Yeromin, A.V., Parker, I., Freites, J.A., Tobias, D.T. & Cahalan, M.D. Molecular biophysics of Orai store-operated Ca 2+ channels. Biophys. J. 108:237-246, 2015. Journal website PDF 55
204) Matheu, M.P., Othy, S., Greenberg, M.L., Dong, T.X., Schujis, M., Deswarte, K., Hammad, H., Lambrecht, B.N., Parker, I. & Cahalan, M.D. Imaging regulatory T cell dynamics and CTLA-mediated suppression of T cell priming. Naure Communications DOI: 10.1038/ncomms7219, 2015. Journal website PDF 78
205) Tan Z, Dai W, van Erp TG, Overman J, Demuro A, Digman MA, Hatami A, Albay R, Sontag EM, Potkin KT, Ling S, Macciardi F, Bunney WE, Long JD, Paulsen JS, Ringman JM, Parker I, Glabe C, Thompson LM, Chiu W, Potkin SG. Huntington's disease cerebrospinal fluid seeds aggregation of mutant huntingtin. Mol Psychiatry doi: 10.1038/mp.2015.81. 2015. Journal website PDF 39
206) Weinger JG, Greenberg ML, Matheu MP, Parker I, Walsh CM, Lane TE, Cahalan MD. Two-photon imaging of cellular dynamics in the mouse spinal cord. J Vis Exp.(96). doi: 10.3791/52580. 2015. Journal website 5
207) Lock JT, Ellefsen KL, Settle B, Parker I, Smith IF. Imaging local Ca2+ signals in cultured mammalian cells. J Vis Exp. (97). doi: 10.3791/52516. 2015. Journal website 11
208) Demuro, A. & Parker, I. Picomolar sensitivity to IP3 in Xenopus oocytes. Cell Calcium.58:511-517. 2015. Journal website PDF 4
209) Ellefsen, K.L., Dynes, J.L. & Parker, I. Spinning-Spot Shadowless TIRF Microscopy. PLoS ONE 10(8): e0136055.doi:101371/journal.pone.0136055. 2015. Journal website. PDF 26
210) Ullah, G., Demura, A., Parker, I. & Pearson, J.E. Analyzing and Modeling the kinetics of Amyloid Beta Pores Associated with Alzheimer's Disease Pathology. PLoS ONE 10(9):e0137357.doi10.1371/jouranl.pone.0137357. 2015. Journal Website. PDF 27
211) Schmunk, G., Boubion, B.J., Smith, I.F., Parker, I. & Gargus, J.J. Shared functional defect in IP3R-mediated calcium sgnaling in diverse monogenic autism syndromes. Nat. Transl. Psychiatry 5:e643; doi:10.1038/tp.2015.123. 2015. Journal Website. PDF UCI Press Release 26
212) Lock, J.T., Parker, I. & Smith. I.F. A comparison of fluorescent Ca2+ indicators for imaging local Ca2+ signals in cultured cells. Cell Calcium 58:638-648. 2015. Journal Website PDF 83
2016-present
213) Lock, J.T., Parker, I. & Smith, I. Communication of Ca2+ signals via tunneling membrane nanotubes is mediated by transmission of inositol trispohosphate through gap junctions. Cell Calcium 60: 266-272, 2016. doi:10.1016/ju.ceca.2016.06.004. Journal website ....PDF 25
214) Dickinson, G.D., Ellefsen, K.L., Dawson, S.P., Pearson, J.E. & Parker, I. Hindered cytoplasmic diffusion of IP3 restricts its cellular range of actions. Science Signaling Vol 9, issue 453,ra108 DOI:10.1126/scisignal.aag1625. (2016) Full text PDF Focus commentary by Luc Laybaert 46
215) Lock, J.T., Parker, I. & Smith, I. Comparison of Ca2+ puffs evoked by extracellular agonists and photoreleased IP3. Cell Calcium 63: 43-47, 2017. Journal website PDF 16
216) Schmunk, G., Nguyen, R.L., Ferguson, D.L., Kumar, K., Parker, I. & Gargus, J.J. High-throughput screen detects calcium signaling dysfunction in typical sporadic autism spectrum disorder. 7:40740 doi:10.1038/srep40740. 2017. Journal website PDF 8
217) Parker, I., Evans, K.T., Ellefsen, K., Lawson, D.A. & Smith, I. Lattice light sheet imaging of membrane nanotubes between human breast cancer cells in culture and in brain metastases. Nature Scientific Reports 7 : 11029 | DOI:10.1038/s41598-017-11223-y. 2017. Open Access 6
218) Tobias X Dong, Shivashankar Othy, Amit Jairaman, Jonathan Skupsky, Angel Zavala, Ian Parker, Joseph L Dynes, Michael D Cahalan. T cell calcium dynamics visualized in a ratiometric tdTomato-GCaMP6F transgenic reporter mouse. eLIFE 2017;6:e32417 doi: 10.7554/eLife.32417. 2017 Open Access 14
219) Tobias X Dong, Shivashankar Oth, Milton L Greenberg, Amit Jairaman, Chijioke Akunwafo, Sabrina Leverrier, Ying Yu, Ian Parker, Joseph L Dynes, Michael D Cahalan. Intermittent Ca2+ signals mediated by Orai1 regulate basal T cell motility. eLife 2017;6:e27827 doi: 10.7554/eLife.27827. 2017 Open Access 11.
220 ) Ellefsen, K.L. & Parker, I. Dynamic Ca2+ imaging with a simplified lattice light-sheet microscope: A sideways view of subcellular Ca2+ puffs. Cell Calcium. 2018 May;71:34-44. doi: 10.1016/j.ceca.2017.11.005. Epub 2017 Dec 1. PDF 20
221) Kyle Ellefsen, Alice Chang, Jamison L. Nourse, Jesse R Holt, Janahan Arulmoli, Armen Mekhdjian, Lisa A Flanagan, Alexander R Dunn, Ian Parker, Medha M Pathak. Piezo 1 flickers localize to hotspots of cellular traction forces. bioRxiv 294611; doi: https://doi.org/10.1101/294611, 2018
222) Ma Z, Taruno A, Ohmoto M, Jyotaki M, Lim JC, Miyazaki H, Niisato N, Marunaka Y, Lee RJ, Hoff H, Payne R, Demuro A, Parker I, Mitchell CH, Henao-Mejia J, Tanis JE, Matsumoto I, Tordoff MG, Foskett JK. CALHM3 Is Essential for Rapid Ion Channel-Mediated PurinergicNeurotransmission of GPCR-Mediated Taste. Neuron. 2018 Apr 13. pii: S0896-6273(18)30249-6. doi: 10.1016/j.neuron.2018.03.043. 2018 [Epub ahead of print] Journal website PDF Commentary by Yuki Oka in Neuron PDF 32
223) Shah, S., Demuro, A., Mak, D-O. D., Parker, I., Pearson, J.E. & Ullah, G. TraceSpecs: A software for automated idealization of noisy patch-clamp and imaging data. Biophys. J. 115;9-21. doi.org/10.1016/j.bpi.2018.06.003. PDF 5
224) Shah SI, Smith M, Swaminathan D, Parker I, Ullah G, Demuro A. Cell Speks: A software for Automated Detection and Analysis of Calcium Channels in live cells. Biophys J. 2018 Oct 25. pii: S0006-3495(18)31163-9. doi: 10.1016/j.bpj.2018.10.015. [Epub ahead of print] PDF 2
225) Kyle L. Ellefsen, Jeffrey T. Lock, Brett Settle, Carley A. Karsten & Ian Parker. Applications of FLIKA, a Python-based image processing and analysis platform, for studying local events of cellular calcium signaling. BBA Molecular Cell Research. 2018. doi.org/10.1016/j.bbamcr.2018.11.012. Journal website 5
226) Lock, J.T., Alzayady, K.J., Yule, D.I. & Parker, I. All three IP3 receptor isoforms generate Ca2+ puffs that display similar characteristice. Sci. Signal 11, eaau0344. doi:10.1126/scisignal.aau0334. 2018. Free online link PDF 13
227) Lock, J., Smith I.F. & Parker, I. Spatio-temporal patterning of Ca2+ signals by the subcellular distribution of IP3 and IP3 receptors. Seminars Call Dev. Biol. doi.org/10.1016/j.semcdb.2019.01.012. e-pub ahead of print. 2019. PDF Free online link 3
228) Kyle L. Ellefsen, Jesse R. Holt, Alice C. Chang, Jamison L. Nourse, Janahan Arulmoli,Armen H. Mekhdjian, Hamid Abuwarda, Francesco Tombola, Lisa A. Flanagan, Alexander R. Dunn,Ian Parker & Medha M. Pathak. Myosin-II mediated traction forces evoke localizedPiezo1-dependent Ca2+flickers. Communications Biology. https://doi.org/10.1038/s42003-019-0514-3. 2019. PDF Open Access 14
229) Divya Swaminathan, George D. Dickinson, Angelo Demuro, Ian Parker. Noise analysis of calcium image data. Cell Calcium. e-pub ahead of print https://doi.org/10.1016/j.ceca.219.102152. 2019. Link to online article PDF 1
230) Jeffrey T. Lock & Ian Parker. IP3-mediated global Ca2+ signals arise through two temporally and spatially distinct modes of Ca2+ release.Elife. 2020 May 12;9:e55008. doi: 10.7554/eLife.55008. eLife website1
231) Horia Vais, Min Wang, Karthik Millilankaraman, Riley Payne, Chris McKennan,Jeffrey T. Lock, Lynn A Spruce, Carly Fiest, Matthew Y Chan, Ian Parker, Steven H. Seeholzer, J. Kevin Foskett, Don-On Daniel Mak. ER-luminal [Ca 2+] Regulation of InsP 3 Receptor Gating Mediated by an ER-luminal Peripheral Ca 2+-binding Protein.2020;9:e53531. doi:10.7554/eLife.53531 eLife website
Commentary by Amanda Wahl and David Yule An inside job: Annexin 1A-Inositol 1,4,5-trisphosphate receptor interaction conveys endoplasmic reticulum luminal Ca2+ sensitivity. Cell Calcium doi.org/10.1016/j.ceca.2020.102250 PDF
232) Shivashankar Othy, Amit Jairaman, Joseph L. Dynes, Tobias X. Dong, Cornelia Tune, Andriy V. Yeromin, Angel Zavala, Chijioke Akunwafo, Fangyi Chen, Ian Parker and Michael D. Cahalan. Regulatory T cells suppress Th17 cell Ca2+ signaling in the spinal cord during murine autoimmune neuroinflammation. Proceedings of the National Academy of Sciences Jul 2020, 202006895; DOI: 10.1073/pnas.2006895117. PNAS website PDF
Commentary by Liewei Wang and Stefan Feske. Seeing is Believing: Visualizing immune cells and calcium signals at different stages of neuroinflammation. PNAS 2020 117 (34) 20360-20362
233) Amit Jairaman, Shivashankar Othy, Joseph L. Dynes, Andriy V. Yeromin, Angel Zavala, Milton L. Greenberg, Jamison L. Nourse, Jesse R. Holt, Stuart M. Cahalan, Francesco Marangoni, Ian Parker, Medha M. Pathak, Michael D. Cahalan. Piezo1 channels restrain regulatory T cells but are dispensable for effector CD4+ T cell responses. Sci. Adv. 2021; 7 : eabg5859. PDF Link to online article
234) Ian Parker, Clarke Slater, Stuart Cull-Candy & Angela Vincent. Ricardo Miledi; 15 September 1927 - 18 December 2017. Biog. Mem. Royal Soc. 2021. doi.org/10.1098/rsbm.2021.0020. PDF free access online article
235) Ian Parker and Jeffrey Lock. Termination of Ca2+ puffs during IP3-evoked global Ca2+ signals. Cell Calcium 100:102494. 2021. PDF Journal website (open access)
236) Jairaman A, McQuade A, Granzotto A, Kang YJ, Chadarevian JP, Gandhi S, Parker I, Smith I, Cho H, Sensi SL, Othy S, Blurton-Jones M, Cahalan MD. TREM2 regulates purinergic receptor-mediated calcium signaling and motility in human iPSC-derived microglia. Elife. 2022 Feb 22;11:e73021. doi: Journal Website (open access) PDF
237) IreneVorontsova, Jeffrey T.Lock, IanParker. KRAP is required for diffuse and punctate IP3-mediated Ca2+ liberation and determines the number of functional IP3R channels within clusters. Cell Calcium. 2022 doi.org/10.1016/j.ceca.2022.102638 PDF Open access
238) Anna Pensalfini , Abdul Rahim Umar , Charles Glabe , Ian Parker , Ghanim Ullah, and Angelo Demuro. Intracellular Injection of Brain Extracts from Alzheimer’s Disease Patients Triggers Unregulated Ca2+ Release fromIntracellular Stores That Hinders Cellular Bioenergetics. Cells 2022, 11, 3630. https://doi.org/10.3390/cells11223630 Open Access
Last updated 05/216 /2023
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