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1
Recommended
F1000 Factor 3.0

New Finding
 'Trigger' events precede calcium puffs in Xenopus oocytes.
Rose HJ, Dargan S, Shuai J, Parker I
Biophys J 2006 Dec 1 91(11):4024-32 [abstract on PubMed] [citations on Google Scholar] [related articles] [full text] [order article]
Selected by | Geneviève Dupont
Evaluated 13 Oct 2006
 
2
Recommended
F1000 Factor 3.0

Controversial
 Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo.
Sanna MG, Wang SK, …, Wong CH, Rosen H
Nat Chem Biol 2006 Aug 2(8):434-41 [abstract on PubMed] [citations on Google Scholar] [related articles] [full text] [order article]
Selected by | Steve Ward
Evaluated 24 Aug 2006
 
3
Recommended
F1000 Factor 3.2

Hypothesis
New Finding
Controversial
 Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary T cells to lymphatic sinuses.
Wei SH, Rosen H, …, Parker I, Cahalan MD
Nat Immunol 2005 Dec 6(12):1228-35 [abstract on PubMed] [citations on Google Scholar] [related articles] [full text] [order article]
Selected by | Steve Ward / Benjamin Cravatt
First evaluation 10 Jan 2006 | Latest evaluation 12 Jan 2006
 
4
Recommended
F1000 Factor 3.2

New Finding
Tech Advance
 Antigen-engaged B cells undergo chemotaxis toward the T zone and form motile conjugates with helper T cells.
Okada T, Miller MJ, …, Cahalan MD, Cyster JG
PLoS Biol 2005 Jun 3(6):e150 [abstract on PubMed] [citations on Google Scholar] [related articles] [FREE full text]
Selected by | James Crowe / Peter Openshaw
First evaluation 20 May 2005 | Latest evaluation 20 Jun 2005
 
5
Must Read
F1000 Factor 4.9

Confirmation
New Finding
Tech Advance
 T cell repertoire scanning is promoted by dynamic dendritic cell behavior and random T cell motility in the lymph node.
Miller MJ, Hejazi AS, Wei SH, Cahalan MD, Parker I
Proc Natl Acad Sci U S A 2004 Jan 27 101(4):998-1003 [abstract on PubMed] [citations on Google Scholar] [related articles] [full text] [order article]
Selected by | Andrea Sant / Rick Tarleton / Michael Dustin
First evaluation 3 Feb 2004 | Latest evaluation 10 Aug 2004
 
6
Exceptional
F1000 Factor 9.0

Tech Advance
 Optical single-channel recording: imaging Ca2+ flux through individual N-type voltage-gated channels expressed in Xenopus oocytes.
Demuro A, Parker I
Cell Calcium 2003 Dec 34(6):499-509 [abstract on PubMed] [citations on Google Scholar] [related articles] [order article]
Selected by | Colin Taylor
Evaluated 18 Dec 2003
 
7
Must Read
F1000 Factor 6.4

Confirmation
New Finding
Tech Advance
 Autonomous T cell trafficking examined in vivo with intravital two-photon microscopy.
Miller MJ, Wei SH, Cahalan MD, Parker I
Proc Natl Acad Sci U S A 2003 Mar 4 100(5):2604-9 [abstract on PubMed] [citations on Google Scholar] [related articles] [full text] [order article]
Selected by | Michael Dustin / Ulrich von Andrian
First evaluation 26 Mar 2003 | Latest evaluation 12 Aug 2003
 
8
Exceptional
F1000 Factor 9.7

Confirmation
New Finding
Tech Advance
 Two-photon imaging of lymphocyte motility and antigen response in intact lymph node.
Miller MJ, Wei SH, Parker I, Cahalan MD
Science 2002 Jun 7 296(5574):1869-73 [abstract on PubMed] [citations on Google Scholar] [related articles] [full text] [order article]
Selected by | Casey Weaver / Jonathan Howard / Matthias von Herrath
First evaluation 14 Jun 2002 | Latest evaluation 1 Jul 2002
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