New paper from the Parker lab: Hindered cytoplasmic diffusion of IP3 restricts its cellular range of action.
In this issue of Science Signaling, Dickinson et al. show that the intracellular messenger inositol 1,4,5-trisphosphate (IP3), which triggers the release of calcium (Ca2+) from the endoplasmic reticulum, is a slowly diffusing local signal, rather than a rapidly diffusing global one. These findings have implications for the understanding of the mechanisms of Ca2+ wave propagation, especially long-range, cell-to-cell propagating Ca2+ waves.
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