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The Parker Lab
Department of Neurobiology and Behavior
University of California, Irvine


1146 Mc Gaugh Hall
University of California, Irvine
Irvine, CA 92697-4550
Lab Tel: 949-824-7833


Cover photo by Ian Parker
on EMBO Journal 

Articles about Ian Parker's research, running and photography have been published in the UCI online magazine, UCI student newspaper, and in the Orange County Register

Science Signaling: 9 (453)

New paper from the Parker lab: Hindered cytoplasmic diffusion of IP3 restricts its cellular range of action.

In this issue of Science Signaling, Dickinson et al. show that the intracellular messenger inositol 1,4,5-trisphosphate (IP3), which triggers the release of calcium (Ca2+) from the endoplasmic reticulum, is a slowly diffusing local signal, rather than a rapidly diffusing global one. These findings have implications for the understanding of the mechanisms of Ca2+ wave propagation, especially long-range, cell-to-cell propagating Ca2+ waves.


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