Images show intracellular Ca2+ signals evoked in a Xenopus oocyte by photorelease of inositol trisphosphate from a caged precursor. Each panel is a surface representation derived from a single image frame captured using a `home-made' video-rate confocal microscope. 

Marchant J and Parker I. Embo Journal 2001, 20: 65-76

Cover was created as an image of the local concentration of Ca2+ in an oocyte of Xenopus laevis induced by photolytically releasing caged inositol 1,4,5-triphosphate.

Stochastic view of lymphocyte motility and trafficking within the lymph node.

Cover illustration represents the motion of T (green) and B (red) cells at the edge of a folicle, and the images were accumulated sequentially in the four panels.

Wei SH, Parker I, Miller M, and Cahalan MD. Immunological Reviews 2003, 195: 136-159.

Cell writing: the series of sequential video frames (30s-1) shows liberation of intracellular calcium in a Xenopus oocyte in response to photorelease of inositol trisphosphate from a caged precursor. Ultraviolet photolysis light was focused onto the oocyte through a mask to form the characters "Ca2+", and the resulting localised liberation of calcium ions from intracellular stores was imaged using a Noran Odyssey confocal microscope to monitor fluorescence of the indicator dye calcium green-5N. The resolution of the characters is in part determined by the spacing between calcium stores in the oocyte which, at about 6um, is appreciably better than achieved by a 600 dpi laser printer.

EMBO Journal, October 2007

Cover photo shows a island in Lake Powell, newly exposed by the falling water level, and framed by sunset reflections of Gunsight Butte.

The image was selected from the annual EMBO photo contest, and will be featured also in the 2008 EMBO callendar.