Faculty of 1000 Biology | Antigen-Engaged B Cells Undergo Chemotaxis toward the T Zone and Form Motile Conjugates with Helper T Cells.

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Antigen-Engaged B Cells Undergo Chemotaxis toward the T Zone and Form Motile Conjugates with Helper T Cells.
Okada T, Miller MJ, Parker I, Krummel MF, Neighbors M, Hartley SB, Ogarra A, Cahalan MD, Cyster JG
PLoS Biol 2005 May 3 3(6):e150 [abstract on PubMed] [related articles] [FREE full text]

Selected by | James Crowe / Peter Openshaw
First evaluation 20 May 2005 | Latest evaluation 20 Jun 2005

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Faculty Comments

Faculty Member	Comments
James Crowe Vanderbilt University School of Medicine, United States of America MICROBIOLOGY New Finding Tech Advance	This paper uses of two-photon microscopy of intact lymph nodes to define the kinetics and anatomy of antigen-specific B-T cell interactions. The work demonstrates that B cells migrate in lymph nodes in a CCR7 gradient-determined fashion. The ability to define the number and duration of cell-cell interactions and the kinetics of chemotaxis leads to some fascinating images and a better understanding of the complexity of in vivo immune responses. Evaluated 20 Jun 2005 cite this evaluation
Peter Openshaw Imperial College London, United Kingdom MICROBIOLOGY New Finding Tech Advance	B cells and T cells need to engage to make a good immune response, but the way they do so has not been visualised before. Using two-photon microscopy, B cells are now seen to move towards the T cell zone of intact lymph nodes after exposure to antigen. Here, they rest for a day before starting to dance through the T cells at a speedy 9 um/min, touching many but lingering over the few that are antigen-specific. The T cells are then 'monogamous and clingy', hanging on to the B cells that continue to move, searching for yet more partners. Evaluated 20 May 2005 cite this evaluation

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How to cite the Faculty of 1000 Biology evaluation(s) for this paper

1) To cite all the evaluations for this article:

Faculty of 1000 Biology: evaluations for Okada T et al PLoS Biol 2005 May 3 3 (6) :e150 http://www.facultyof1000.com/article/15857154/evaluation

2) To cite an evaluation by a specific Faculty member:

James Crowe: Faculty of 1000 Biology, 20 Jun 2005 http://www.facultyof1000.com/article/15857154/evaluation

Peter Openshaw: Faculty of 1000 Biology, 20 May 2005 http://www.facultyof1000.com/article/15857154/evaluation

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