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F1000 Factor 3.2

Antigen-Engaged B Cells Undergo Chemotaxis toward the T Zone and Form Motile Conjugates with Helper T Cells.
Okada T, Miller MJ, Parker I, Krummel MF, Neighbors M, Hartley SB, Ogarra A, Cahalan MD, Cyster JG
PLoS Biol 2005 May 3 3(6):e150 [abstract on PubMed] [related articles] [FREE full text]
Selected by | James Crowe / Peter Openshaw
First evaluation 20 May 2005 | Latest evaluation 20 Jun 2005
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Faculty Comments
Faculty Member Comments
James Crowe
Vanderbilt University School of Medicine, United States of America

New Finding
Tech Advance
This paper uses of two-photon microscopy of intact lymph nodes to define the kinetics and anatomy of antigen-specific B-T cell interactions. The work demonstrates that B cells migrate in lymph nodes in a CCR7 gradient-determined fashion. The ability to define the number and duration of cell-cell interactions and the kinetics of chemotaxis leads to some fascinating images and a better understanding of the complexity of in vivo immune responses.

Evaluated 20 Jun 2005
Peter Openshaw
Imperial College London, United Kingdom

New Finding
Tech Advance
B cells and T cells need to engage to make a good immune response, but the way they do so has not been visualised before. Using two-photon microscopy, B cells are now seen to move towards the T cell zone of intact lymph nodes after exposure to antigen. Here, they rest for a day before starting to dance through the T cells at a speedy 9 um/min, touching many but lingering over the few that are antigen-specific. The T cells are then 'monogamous and clingy', hanging on to the B cells that continue to move, searching for yet more partners.

Evaluated 20 May 2005
Faculty Comments

How to cite the Faculty of 1000 Biology evaluation(s) for this paper

1) To cite all the evaluations for this article:

Faculty of 1000 Biology: evaluations for Okada T et al PLoS Biol 2005 May 3 3 (6) :e150 http://www.facultyof1000.com/article/15857154/evaluation

2) To cite an evaluation by a specific Faculty member:

James Crowe: Faculty of 1000 Biology, 20 Jun 2005 http://www.facultyof1000.com/article/15857154/evaluation

Peter Openshaw: Faculty of 1000 Biology, 20 May 2005 http://www.facultyof1000.com/article/15857154/evaluation

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